The Impotence of Deterrence

The failure of MAD against madmen is the subject of this post from Powerline:

One of the insoluble difficulties raised by Iran's nuclear threat is the impotence of deterrence against those who relish death, or think death but a small price to pay for the elimination of Jews from "Palestine." The unworkability of deterrence against Iran has received remarkably little public attention, though it must have something to do with the assertion that Iran's acquisition of nuclear weapons would be "unacceptable."

The answer can only be "regime change" against such people.